Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity
نویسندگان
چکیده
Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic acid had a positive influence on the cytotoxicity. Up to 69% of HeLa and 65% of KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg/mL).
منابع مشابه
A study on the catalytic activity of a new acidic ordered mesoporous silica (SBA-15)
SBA-15 is an interesting mesoporous silica material having highly ordered nanopores and a large surface area, which is widely employed as a catalyst. This mesoporous silica due to silanol groups is easily functionalized by various organic materials. A new acidic ordered functionalized mesoporous silica (SBA-15-Aminopropyl-Benzyl-SO3H) has been introduced as an efficient catalyst for ...
متن کاملSBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity
Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).
متن کاملA study on the catalytic activity of a new acidic ordered mesoporous silica (SBA-15)
SBA-15 is an interesting mesoporous silica material having highly ordered nanopores and a large surface area, which is widely employed as a catalyst. This mesoporous silica due to silanol groups is easily functionalized by various organic materials. A new acidic ordered functionalized mesoporous silica (SBA-15-Aminopropyl-Benzyl-SO3H) has been introduced as an efficient catalyst for ...
متن کاملA novel diethyl 2-(9-fluorenyl) malonate functionlized SBA-15 for selective optical sensing of Iron
In this study, highly ordered mesoporous silica material (SBA-15) functionalized with Diethyl 2 - (9 -fluorenyl) malonate as a flourophore is reported. The anchoring of flourophores to the hydroxyl group on SBA-15 surface was done with post synthesis method. The obtained materials were characterized by small and wide angle X-ray diffraction, N2 adsorption–desorption, Fourier transform infrared ...
متن کاملBiginelli Multicomponent Condensation Reaction Promoted by 4,4ʹ-Bipyridinium Dichloride Ordered Mesoporous Silica Nanocomposite under Solvent Free Conditions
In this paper, 4,4ʹ-bipyridinium dichloride supported SBA-15 (SBA@BiPy2+ 2Cl-) was used for the synthesis of dihydropyrimidinones. The synthesized catalyst was characterized by FT-IR spectroscopy, scanning electron microscopy (SEM), Transmission electron microscopy (TEM) and Thermogravimetric analysis (TGA). This nanocomposite was shown to be an efficient heterogeneous ca...
متن کامل